Workshop A: BBB Masterclass (BBB 101, with a Hint of 401) – Grasping the Basics with the BBB
Monday, June 28 | 10AM - 1PM EST
This workshop is designed to get you up to speed with where we are in our current understanding of the BBB and industry efforts to penetrate the BBB.
We will discuss the following topics:
Pres. 1. (Maria) 50 min + 10 min questions & discussion
- What is the BBB? (morphology, anatomy)
- Understanding the fundamental aspects of the cell biology of the BBB (cell types, function)
- Modelling the BBB: from microvessels to organ on chip and human studies
- What are we yet to uncover in terms of the BBB biology? (cell-cell crosstalk and regulation
Pres. 2. (Bill) 50 min + 10 min questions & discussion
- Transporters/receptors (BBB development and heterogeneity; how does age and heterogeneity impact function?)
- What happens with the blood brain barrier in aging and different diseases? (drug transport in aging and diseases)
Part 3: Q&A - BBB-related questions, problems or aspects from participants
William A. Banks
Associate Chief of Staff, Research & Development, VA Puget Sound
Professor, Division of Gerontology & Geriatric Medicine, Department of Medicine University of Washington
Maria Deli, Scientific Adviser, Group Leader
Biological Research Centre, Szeged, Hungary
Workshop B: Harnessing Mass Spectrometry Imaging to Investigate Distribution & Metabolism of Drugs Across the BBB
Monday, June 28 | 2PM - 4PM EST
- Assessing the spectrum of drug permeability, what makes a drug distribute across the BBB?
- Extensive imaging of targeted therapies that transit through the blood-brain barrier in pre-clinical animal models and clinical trial patients
- Approaches to developing and implementing mass spectrometry and optical imaging approaches for surgical pathology and oncology
- What other hurdles must be overcome to enable homogenous distribution of drugs to the CNS?
- Key learnings and insights from oncology that canprovide food for thought for BBB experts across neurodegenerative diseases Leave the workshop with an understanding of mass spectrometry approaches to assess BBB permeability and regional heterogeneity.
Nathalie Y.R. Agar
Daniel E. Ponton Distinguished Chair in Neurosurgery, Harvard Medical School
Associate Professor of Neurosurgery, Brigham and Women’s Hospital, Department of Cancer Biology
Associate Professor of Radiology, Dana-Farber Cancer Institute