Blood-Brain Barrier Delivery in Non-Human Primates by Single Domain VNAR Antibodies to TfR1

Time: 11:00 am
day: Day One

Details:

  • Ossianix developed multiple BBB shuttles based on single domain VNAR antibody that were shown to deliver functional payloads to brain in mouse models
  • New lead antibody TXP1 with specificity to human and cyno TfR1 showed efficient brain penetration in non-human primates
  • When administered at 1.35mg/kg, TXP1 reached ~4nM concentration in brain at 20-hour timepoint
  • In comparison to negative control, TXP1 showed over 30-fold increase in hippocampus

Speakers: